Well IMHO Penfed's cards are mostly ho-hum these days both in terms of the earning rewards and the redemption rate. There is also a disappointing 50k max across card products (although for years I was over this until last year when they fixed the glitch). The whole Penfed turns people down for "pyramiding debt" that was something that happened to CW's back in the day but it has been years since I've seen such a claim.
Of the three issuers you list, amex has the best options unless your spending patterns would favor a product from wells or penfed. Last time I look at wells products I was underwhelmed.
My point about penfed above is merely it should not necessarily be listed with FNBO, us Skank, and the others since we have not seen many (any?) reports of Egyptian adverse action in the past decade.